Misoprostol is rapidly metabolized from the mom to misoprostol acid, that's biologically active and is excreted in breast milk.???? ???? ??? ???????? ??? ?????????? ??????? ??????? ??? ??????? ???? ???????? ???????? ????? ???? ?????? ????? ????? ????? ????????? ???????. ???? ????????????? ?? ??????? ???? ?????. ???? ??????? ?????.See BOXED WARNING